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yersinia pestis Plague Pandemics: The Three Waves of Devastation Caused by Yersinia pestis The bacterial disease known as plague has been responsible for some of the deadliest pandemics in human history. Over countless centuries, Yersiiinia pestis has unleashed three major waves of plague that decimated global populations.  In this article, we will explore the Yersinia pestis: Three Pandemics Called Black Death. The First Pandemic: Justinian Plague (6th Century) The first documented plague pandemic originated in Egypt in 541 AD. Known as the Plague of Justinian, it spread swiftly along trade routes throughout the Byzantine Empire and Mediterranean world. Transmitted by rat fleas, it primarily caused painfully swollen buboes in lymph nodes which could turn gangrenous or fatal without treatment. Historical sources indicate communities saw up to 50% of their population perish within just a few months. It continued periodically into the 8th century, severely weakening the Eastern Roman...